The scientific rigor that goes into our unique formulation.
The Detergent Mildness* Index (DMI) uses a series of three tests commonly used in the skin-care industry to measure product mildness. all® free clear was shown to be the mildest* sensitive-skin laundry detergent.
Zein Test: Measuring protein damage
The Zein Test indicates levels of potential irritancy by analyzing protein damage in the outer layer of skin. This test shows all® free clear maintains skin protein better than other sensitive-skin detergents.
Corneosurfametry Test: Measuring protein and lipid degradation
The Corneosurfametry Test assesses the degradation of stratum corneum proteins and lipids using top layers of skin that are soaked in detergent, and then placed in a dye to highlight damage. More staining reflects more cell damage.
Here you see that all® free clear is even similar to the control: water.
Cytokine Test: Measuring inflammatory response
The Cytokine Test goes deeper to measure inflammatory response due to detergent exposure by testing levels of keratinocyte-derived IL-1⍺.
all® free clear shows minimal response, with skin layers remaining clearly defined.
Watch this short video used at dermatology conferences. It helps explain the testing that shows all® free clear is the mildest detergent for patients with sensitive skin.*
Hear from our board certified Dermatologist Matthew Zirwas about the science of all® free clear and why we are the mildest* detergent for sensitive skin.
*Mildest amongst leading sensitive-skin laundry detergents. Milder using combination of 3 tests: zein, cytokine, and corneosurfametry. Patch test results were the same across all sensitive-skin detergents. 2024 data.
Deep dive into the data
A comprehensive understanding on how detergent can affect skin.
The Detergent Mildness Index (DMI) was used to measure the mildness of several laundry detergents in three laboratory tests: zein, cytokine and corneosurfametry.
This paper illustrates that certain surfactant compositions in laundry detergents can provide a mild character for sensitive skin.
all® free clear fabric softener, which is free of fragrances and dyes, was ranked as mild and elicited no experimental irritation in a 14-day cumulative irritation study.